The Aptima HPV assay, using goal seize and transcription-mediated amplification expertise, detects the presence of messenger RNA (mRNA) from high-risk human papillomavirus (HPV) varieties 16, 18, and 45. These particular genotypes are strongly related to the event of cervical most cancers. This check differs from DNA-based checks by figuring out energetic viral transcription, providing perception into the potential for illness development.
Detecting E6/E7 mRNA from HPV 16, 18, and 45 offers a extra exact evaluation of cervical most cancers threat than merely figuring out the presence of viral DNA. This enables for simpler triage of sufferers for additional diagnostic procedures, reminiscent of colposcopy, and might contribute to earlier intervention and improved affected person outcomes. The event of mRNA-based HPV testing represents a major development in cervical most cancers screening, enabling a extra nuanced and focused method to threat stratification.
